Cialis [Tadalafil] is an almond shaped oral pill used for erectile dysfunction treatment. The active ingredient present in Cialis is viagra cialis online pharmacy pharmacy. In each tablets 2.5 5 10 or 20mg of tadalafil and other inactive ingredients are constituted. Tadalafil present in Cialis is a Phosphodiesterase type 5 PDE5 Inhibitor. Sex stimulation releases Nitric Oxide NO which stimulates the synthesis of cyclic guanosine monophosphate cGMP in smooth muscle in penis and relaxes it and increases blood flow to the corpus cavernosum of penis causing penile erection. Cialis’s pharmacologic distinction is its longer half-life 17.50 hours or 36 hours effectiveness compared to other PDE5 inhibitors like Viagra and Levitra which are 4-5 hours resulting in longer duration of action. That is why it has earned a nickname’ The Weekend Pill ’. Cialis has recently been approved for the treatment of Pulmonary Arterial Hypertension PAH minimizing the risk of right heart failure and respiratory failure. Cialis is considered as one of the best erectile dysfunction drugs.
Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis and at the same time the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis.
Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis. The nitric oxide causes an enzyme guanylate cyclase to produce cyclic guanosine monophosphate cGMP. It is the cGMP that is primarily responsible for increasing and decreasing the size of the blood vessels carrying blood to and from the penis respectively and causing the erection. When the cGMP is destroyed by another enzyme phosphodiesterase-5 the blood vessels return to their normal size blood leaves the penis and the erection ends. Tadalafil prevents phosphodiesterase-5 from destroying cGMP so that cGMP stays around longer. The persistence of cGMP leads to a more prolonged engorgement of the penis with blood.
Tadalafil was approved by the FDA in November 2003.
http://www.iwantmeds.com/medicine-generic/Cialis-Generic/89.html
gå ner i vikt
